Choline (Vitamin B4) is a natural organic compound which, when crossing the blood-brain barrier, acts on the central nervous system. It allows you to maintain the normal condition of neurons and affects the development of new cells. In addition, it improves the integrity and fluidity of nerve cells. It affects the improvement of memory. Choline improves inter-neuronal signaling and plays a key role in brain development. It is also believed that vitamin B4, through the formation of cell membranes, affects the integrity of neurons, and also protects them from the harmful effects of external factors.
Ueland P.M., Choline and betaine in health and disease, J Inherit Metab Dis., 2011
Cohen BM, et al., Decreased brain choline uptake in older adults. An in vivo proton magnetic resonance spectroscopy study, JAMA., 1995
The relation of dietary choline to cognitive performance and white-matter hyperintensity in the Framingham Offspring Cohort, Coreyann Poly, Joseph M Massaro, Sudha Seshadri, Philip A Wolf, Eunyoung Cho, Elizabeth Krall , Paul F Jacques, and Rhoda Au
Nutrition, the brain and cognitive decline: insights from epigenetics. Eur J Clin Nutr. Nov 2014; 68 (11): 1179-85. doi: 10.1038 / ejcn.2014.173. Epub 2014 Sep 3.Citicoline improves verbal memory in aging. Spiers PA1, Myers D, Hochanadel GS, Lieberman HR, Wurtman RJ.